Important safety information
What you should know before taking facial estriol. Please see the full Prescribing Information for complete safety information.
Estradiol (estrogen) cream, 0.1%
How Evernow works


Relieve your menopause symptoms

Bioidentical hormone therapy
Relief from menopause symptoms
Supports long-term health
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of Evernow members feel better within 8 weeks*
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Frequently Asked Questions
Transdermal estradiol cream is a compounded estrogen medication applied to the skin. It delivers systemic hormone therapy for menopause symptoms.
The cream is absorbed through the skin into the bloodstream, providing systemic estrogen support. This route avoids liver metabolism and may reduce the risk of blood clots compared to oral estrogen.
It may be appropriate for women who cannot tolerate pills or patches, or who need dosing adjustments not available in standard formulations. Your Evernow provider will evaluate whether this option is right for you.
Compounded medications are made by licensed pharmacies using FDA-approved ingredients. The final formulation is not FDA-approved but allows for dose adjustments that standard products may not offer.
Bioidentical estrogen has the same molecular structure as the estrogen your body produces naturally. It is plant-derived and used in many FDA-approved HRT formulations.
Click Get Care and select your preferred type of care - a virtual visit or membership. You'll connect with a licensed clinician trained in menopause to develop a personalized care plan. Any medications you are prescribed can be sent to your local pharmacy or delivered to your home.
Yes. We accept insurance for video visits from major plans like UnitedHealthcare, Aetna, Anthem, and Blue Cross Blue Shield. Medications are also covered by commercial insurance if picked up at your local pharmacy. Most out of pocket costs with Evernow are also FSA/HSA eligible.