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Important safety information

Your Evernow provider will determine which vaginal estradiol cream is right for you. Please make sure to read all of the important safety information included in your medication packaging before starting this medication. If you are concerned that you are having side effects related to the medication, please contact your Evernow medical provider through our platform.

FDA-Approved
Bioidentical
Insurance eligible

Vaginal estradiol (estrogen) cream

A bioidentical, FDA-approved estrogen-based vaginal cream proven effective for treating genitourinary syndrome of menopause (GSM).
Relieve menopausal symptoms
Connect with a provider within 24 hours
Prescriptions covered by most insurance
Pharmacy pickup or at-home delivery
HSA/FSA eligible membership — starting at $35/month
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cream
Get Free vaginal estrogen cream* (worth up to $480/year)
with a multi-month membership
*Must medically qualify and be on a 3-or-12-month plan
Learn more
What it is

Vaginal estrogen is localized hormone therapy that comes in the form of a 0.1% estradiol cream. 

It is both a preventative therapy and solution for GSM (genital, sexual, urinary) symptoms like vaginal dryness, frequent UTIs, and painful sex. These symptoms are actually very common, affecting 84% of menopausal women.

Vaginal estrogen is localized hormone therapy that comes in the form of a 0.1% estradiol cream. 

It is both a preventative therapy and solution for GSM (genital, sexual, urinary) symptoms like vaginal dryness, frequent UTIs, and painful sex. These symptoms are actually very common, affecting 84% of menopausal women.

What to expect

Some women begin to feel relief in as little as a few weeks and overall symptom relief may take up to three months. 

To maintain results, continue to utilize the cream as prescribed.

Some women begin to feel relief in as little as a few weeks and overall symptom relief may take up to three months. 

To maintain results, continue to utilize the cream as prescribed.

How to use

The cream comes with an applicator that you fill and insert into your vagina. You can also use cream around the entryway to your vagina, including on and around your urethra and clitoris. 

Use the cream twice a week. If you have more severe symptoms, consider starting with a loading dose of using the cream every night for two weeks. We recommend doing so right before bed, as this allows the cream to absorb.

The cream comes with an applicator that you fill and insert into your vagina. You can also use cream around the entryway to your vagina, including on and around your urethra and clitoris. 

Use the cream twice a week. If you have more severe symptoms, consider starting with a loading dose of using the cream every night for two weeks. We recommend doing so right before bed, as this allows the cream to absorb.

Important safety information
cream
Get Free vaginal estrogen cream* (worth up to $480/year)
with a multi-month membership
*Must medically qualify and be on a 3-or-12-month plan
Learn more
The Science Behind

Vaginal estradiol cream can relieve common menopause symptoms

Recurrent UTIs
Incontinence
Vaginal Dryness
Painful Sex
Urinary Discomfort
Recurrent UTIs
Incontinence
Vaginal Dryness
Painful Sex
Urinary Discomfort

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Send your provider a message at anytime to adjust your medications or raise any new questions or concerns.

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FAQs

What is vaginal estradiol (estrogen) cream?

It is an FDA-approved vaginal treatment that helps relieve genitourinary syndrome of menopause (GSM). Vaginal cream is made of 0.1% estradiol cream and is bioidentical. 

What are Genitourinary Syndrome of Menopause (GSM) symptoms?

84% of women within 6 years of menopause face GSM symptoms, impacting quality of life. Symptoms include vaginal dryness, painful sex, more UTIs, and decreased vaginal health.

How does vaginal estradiol cream work?

Vaginal estrogen is absorbed through the vagina and comes in the form of a cream or a tablet. It directly treats the root cause of symptoms by returning your estrogen levels to normal to restore tissue, blood flow, collagen, and function. Unlike systemic hormone therapy, pills, or patches, it works at the source and specifically on GSM symptoms.

How do you use vaginal estrogen cream?

The cream comes with an applicator that you fill up and insert into your vagina. You can also split the dose of estrogen cream between the inside and entryway to your vagina, including on and around your urethra and clitoris. 

Use the cream twice a week. We recommend doing so right before bed, as this allows the cream to absorb.

Can you use vaginal estrogen cream preventatively, and how long can I use it?

Yes! Proactive use of vaginal estrogen prevents symptoms like pain, tearing, dryness, and tissue shrinkage. Its low-dose formula makes it safe for women of any age, with no age restrictions—you can start and stop anytime.

Is vaginal estrogen cream safe?

Low-dose vaginal estrogens are safe for nearly every woman and can be used proactively. It is absorbed locally rather than systemically and doesn’t require the concurrent use of progesterone. Consult your provider to get started.

Can you take vaginal estrogen cream while using hormone therapy (HT)?

Yes! It is possible to take systemic and vaginal hormones together to address menopausal symptoms.

Vaginal estrogen can also be used by women with a history of breast cancer, who may not be able to use systemic HRT.

Should I consider pelvic floor exercises in addition to vaginal estrogen cream?

Pelvic floor exercises help with stress incontinence and sexual discomfort. They strengthen muscles and can complement vaginal estrogen. Find targeted exercises on Evernow's Learn platform.

Why does vaginal estrogen cream have a black box warning?

The FDA's black-box warning on vaginal estrogen cautions against systemic estrogen risks like endometrial cancer, cardiovascular disorders, breast cancer, and dementia. However, many medical societies argue that localized, lower-dose vaginal estrogen lacks evidence linking it to these conditions. Organizations continue to advocate for FDA language updates to represent risks accurately.
Learn more.

What do I need to know about getting vaginal estrogen cream with my membership?

All 3 and 12-month memberships will get you access to a free 90-day supply of vaginal estrogen, for those who medically qualify. The supply continues to renew every 90 days as long as your membership is active.

If you cancel your membership or switch to a one-month membership plan, you will no longer have access to free vaginal estrogen.

How is vaginal estrogen cream different from moisturizers and lubricants?

Lubricants and vaginal moisturizers work differently from vaginal estrogen. While lubricants and moisturizers provide comfort by adding moisture or lubrication, they don’t change the vaginal tissue itself. Vaginal estrogen, on the other hand, activates receptors in the vagina to restore the tissue's natural structure. Since the root cause of GSM (Genitourinary Syndrome of Menopause) is a decrease in estrogen, vaginal estrogen treatments are the most effective solution.

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