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Estradiol Patch

$55/month

Membership fee billed separately

Estradiol is the most effective treatment for the most common menopausal symptoms.

Get Estradiol

Bioidentical

FDA-approved

Prescriptions covered by most insurance

FSA/HSA may be eligible

*Plus the cost of $49/month Evernow Membership

Product Details

FDA-approved Estradiol, as part of a menopausal hormone therapy regimen, is the most effective treatment for the common symptoms (e.g., hot flashes, night sweats, insomnia, vaginal dryness) of menopause.

What to expect

By 2 weeks, most women start to feel the benefits of the treatment, including a reduction in hot flashes and night sweats, and better sleep. Full relief is typically seen by 1-3 months.

How to use

The patch is very easy to use. The packaging insert has a guide for you to reference, but here are the basics: You just place it on your skin like a bandaid. The typical locations for patch placement are the lower abdomen or upper buttock. Most women rotate the patch on their lower abdomen or buttock from side to side, to help prevent irritation. You will need to change your patch every 3 and 4 days. Some people stick to a Monday and Thursday or Tuesday and Friday routine (whichever day combo you want). If you find that you forget to switch the patch on those days, it helps to set an alarm on your phone.

If you forget to apply your next patch on time, it’s no big deal, but you may get some resurgence of symptoms (e.g., hot flashes) as the medication in each patch diminishes over time. Your patch may fall off early if you are an avid daily swimmer or hot tubber. If you are a regular swimmer, you may consider covering the patch with a waterproof bandaid when you swim, but you won’t need to for regular bathing/showering.

Safety information

Please make sure to read all of the important safety information before starting this medication. If you are concerned that you are having side effects related to the medication, please contact your Evernow medical provider through our platform.

Product Details

What to expect

By 2 weeks, most women start to feel the benefits of the treatment, including a reduction in hot flashes and night sweats, and better sleep. Full relief is typically seen by 1-3 months.

How to use

Safety information

See more details

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This page has been medically reviewed by , MD ()

Frequently asked questions

Where to apply the estradiol patch?

The patch is very easy to use. The packaging insert has a guide for you to reference, but here are the basics: You just place it on your skin like a bandaid. The most common sites of application are the lower abdomen and upper buttocks. To avoid irritation, it helps to change the site of application each time (i.e., rotate between the sides of the abdomen or buttocks). The patch should be changed every 3 and 4 days (e.g., Monday & Thursday or Tuesday & Friday). If you forget to change your patch, it’s no big deal, but the medication will decrease over time, so you may get some resurgence of symptoms, like hot flashes or night sweats. This will also happen if the patch falls off on accident. The adhesive is durable and it is rare that a patch dislodges by accident. If you are a regular swimmer, you may consider covering the patch with a waterproof bandaid when you swim, but you won’t need to for regular bathing/showering. Pro tip: Set a reminder in your calendar or a recurring alarm on your phone to help you remember to swap your patch!

How to keep the estradiol patch on?

Make sure that the site of application is free of any lotion, oil, and powder.

Position your patch in an area that won’t be irritated by clothing or crease from movement (ideal areas for patch placement are lower abdomen and on the upper buttocks below the panty line)

Press and spread the patch out firmly with the palm of your hand

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How long does it take the estradiol patch to start working?

By 2 weeks, most women start to really feel the benefits of the treatment, including a reduction in hot flashes and night sweats, better sleep, and decreased vaginal dryness. This is normal, and will even out over time. Full relief is expected between 1-3 months. We will check in with you a little more often while you are getting started and then monthly, but please reach out to our providers any time if you have questions.

Are estradiol patches safe?

The estradiol patch is typically well tolerated, but there are some common side effects to be aware of. Nausea, headache, abdominal bloating, breast pain, vaginal spotting, and irritation at the placement site can occur. These side effects are typically time-limited and go away in the first few months of use.

Use of estrogen may be associated with an increased risk of heart attack, stroke, blood clots in the legs or lungs, breast cancer, uterine cancer, or dementia. Evernow prescribes the generic equivalent of Vivelle-Dot. Be sure to check out the safety information for Vivelle-Dot, and talk to your Evernow medical provider about possible contraindications, especially if you have a history of estrogen-sensitive cancer, undiagnosed vaginal bleeding, coronary heart disease, blood clots, or stroke.

Important Safety Information

What you should know before taking Estradiol Patch

Read safety information

Important Safety Information

About off-label treatments

The FDA approval process requires a rigorous clinical testing process to ensure a drug is safe and effective to treat a particular condition or indication. “Off-label” use is when a provider prescribes an FDA approved drug for an unapproved use (conditions that go beyond its approved indications). Such “off-label” prescribing is legal and commonly practiced. Healthcare providers have the discretion to prescribe drugs off-label if deemed appropriate for a patient based on their medical history, symptoms and preferences.

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